I don't think you need to even go that far to begin questioning whether or not someone continues to be themselves. Even advanced cybernetics would cause that question to occur. If you body is somewhat replaced or largely enhanced, are you still "you?" How much of are self is based on the relationship between the mind and the body. If one changes, are we still ourselves? Think about dementia; that is why it is so frightening to so many people because we fear losing ourselves when our mind goes.
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