I believe it has to do with the blood type. The British royal family have Rh negative blood type. Causes all sorts of problems with their reproduction. & is thought to have a connection to reptiles blood. Although this has never been verified.
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They seem to be breeding like rabbits at the moment, though with bloodlines from outside of their normal "class" as in non royals.
Years ago they had to marry other royals, usually from Germany or other European countries, not so much now though.