I am happy and joyful while thinking and exploring! The 1/3 number is an estimate. No one knows how many people are really affected as it varies between places in the world. I can't really answer those questions, but I can speculate. Toxo is known to make mice sexually attracted to their predators and some studies have shown that in humans it can lead to reduce seeking of novelty and higher risk of schizophrenia. So it would affect you on your spiritual path by making you complacent so you stop thinking and exploring new things. The goal would seem to be to make us as sedentary and boring as possible, like herd animals, sheep if you will. I think even those infected with it can overcome it mentally even without drugs or treatment.
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"I think even those infected with it can overcome it mentally even without drugs or treatment." - Totally agree with you! I am sure that we can find many microbiological and physiological explanations why we are complacent, aggressive, lazy, but only one way out is self-development.