As a person who had severe bipolar disorder, I believe that a positive attitude and healthy mindset play a bigger role in determining a person’s mental state, genetics is only a small factor in all of this.... don’t let genes change who you really are!
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Living example here on that statement. Be well
Yes, the genome gives basically the set to define an individual but the transcriptome and the epigenome can be modified and consequently change the individual during his life. This is why this study is important, nobody is genetically doomed to be alcoholic.
And yes, this is also why have a good mental state may affect genes expression (transcriptome and epigenome).