Many factors to take into account, but I can't help but look toward the fields that have been sprayed with poisons for generations now the world over. This practice was bound to have unintended and dire consequences, and I'm afraid we may not yet know just how far the effects of such methods could reach.
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and nowadays, they don't spray as much insecticide. Instead, they treat the seeds with poison and the plants incorporate the poison into their tissues. This is currently routine practice for soybeans and corn and huge variety of other crops. Very deadly to insects. But don't worry, it apparently has no effect on us (sarcasm). Bon appetit.