So one simply had to "feed" the cancer well enough to prevent a strong expression of ATF4 to keep the normal level of the expression of MITF to prevent metastasis. ;-) Then at least one had only to fight against one big aggregation of cancer cells instead against many small ones.
(Don't take that too serious, I know it won't be easy anyway whatever we try to do.)
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As more pieces of the puzzle get filled in, hopefully we will slowly figure out better possible treatments, yeah. You're right that no matter what direction we go in, its going to be tough work. The complexities of cancer are very very great.