Today I am going to try something different. I am going to write an extremely brief post about a cool topic, no long detailed background section (that will be reserved for my weekend posts), no extensive data discussion, no detailed breakdown. This is a brief report!
Todays article of choice is titled "Tracing and Characterizing the Development of Transplanted Female Germline Stem Cells In Vivo," and was published online in the journal Molecular Therapy.
The authors were doing some experimentation to try to tackle sterility. There are a lot of reasons why someone can become sterile: you could be born that way, or perhaps had cancer and received chemo therapy or radiation therapy. What if we could use stem cells to allow people who are sterile, to re-gain their reproductive abilities? Wouldn't that be amazing? Well this is precisely what the authors of this article accomplished... in mice.
Briefly... What Did They Do?
Recently (in mice... of course) researchers had illustrated how to isolate and culture female germline (this means reproductive) stem cells, and that these cells are capable of producing babies. [2]. What had not been studied, was whether these stem cells could be implanted into the ovaries of sterile mice, and whether or not doing so would allow the mice to get pregnant.
The authors isolated the female germline stem cells from a newborn mouses ovary, and cultured them based on a recently published protocol. [3] They found that the stem cells grew well and had normal numbers of chromosomes, aka nothing weird was going on.
The authors then generated a green fluorescent version of these germline stem cells, and implanted them into an ovary (they wanted to visualize where they went!) They found that they migrated to the edges of the ovary with in a couple days after transplantation. After 6 days they observed that some of the cells were getting larger, which suggested to the authors that they were beginning to differentiate into egg cells.
They next wanted to see if this could happen in a sterile ovary, and perhaps restore fertility to a poor sterile little mouse (remember the goal from all of this is to potentially treat sterile humans). So they implanted the germline stem cells, then waited two months. At that point they investigated what was going on in those infertile mice and they saw that there were egg cells in various stages of development. Next they wanted to see if the mice could actually get pregnant.
To do this they put mice in two little cups and had them kiss (like the gif above)... kidding. They let those mice go to bone-town, and found that 75% of the stem cell recipient mice were able to get pregnant. Not bad!
Very Brief Conclusions
Ovarian derived stem cells (from young mice) were transplanted into infertile mice, and that transplantation restored the ability of those mice to get pregnant and have babies.
The authors work here appears to have laid down the fundamental ground floor for the development of a future means to treat infertility.
Sources
- http://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(17)30180-6
- https://www.nature.com/ncb/journal/v11/n5/full/ncb1869.html
- http://www.nature.com/protocolexchange/protocols/2552
All Non Cited Images Are From Pixabay.com And Are Available Under Creative Commons Licenses
Any Gifs Are From Giphy.com and Are Also Available for Use Under Creative Commons Licences
I don't expect this brief article to make a splash, however I will be distributing all SBD rewards in the form of Steem Power out equally to anyone who comments in this article (commenting more than once will not gain you more, it will be calculated per user, the fewer user comments the bigger your potential prize... the more comments, smaller your prize, everyone who comments will get something).
I am doing this as an experiment to see who actually reads down here ;)
If you like this work, please consider giving me a follow: @justtryme90. I am here to help spread scientific knowledge and break down primary publications in such a way so as to cut through the jargon and provide you the main conclusions in short (well compared to the original articles at least!) and easy to read posts.
I have a feeling most of the people who commented didn't even read that part at the end
I don't suspect they did. However they will be surprised in 7 days won't they :)
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
@justtryme90
I commend you for your research that you compiled for this very informative post!
Stem cell technology, though still evolving, is offering hope to individuals around the world. I think it's very exciting to think that infertile couples might stand to benefit from this.
I've also been hoping that stem cell technology could one day help my dad who is immobile due to a stroke he had back in 2012.
Thanks again for sharing this with the community! :)
Yeah this was a really cool paper. The procedure that the authors followed doesn't seem all that difficult so it stands to reason that a treatment could come out of this and subsequent works fairly quickly (quickly in the science world is still probably 10 or more years though...)
Yeah I tried to keep this post really short and straight to the point.
Sorry to hear about your Dad's stroke! I really think that stem cell technology holds massive promise for being able to help treat cases like that where there is damage to tissue that is unable to repair itself. I hope that the technology progresses quickly enough to help your father, I am sure there are many others out there in similar situations as well.
@justtryme
Yes, you did present your post very concisely and I appreciate your high quality content! Thank you for what you said and for the well wishes for my dad. It hasn't been an easy journey, but hopefully these technologies will be developed in such a way that he would benefit from them! We'll wait and see I guess.
Have a great evening! :)
You too my friend.
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
You're most welcome! It was my pleasure! :)
So friend @justtryme90 I really appreciate your blogs because we both share similar interests. so guy @sykochica suggested me to interact with you. I am really struggling to get into limelight on steemit And I am constantly trying to make health related posts. I would like to connect.
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
Thank you my friend
You're welcome man.
Are you in steemit.chat? If so, join the room #steemSTEM you can also feel free to direct message me. I don't know what help I can be, but if you've got good posts I will try my best :)
Thank you very much @justtryme90 . It would be great to share our ideas
Quite interesting! Upvoted @justtryme90 . Please upvote and follow me @digitaldollar
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
Thank you my dear friend! Its great you kept your promise..
I am a man of my word, I don't make promises I don't intend to keep. You are welcome, and I thank you for your support of me.
Thanks for reading @digitaldollar, and also for your nice comment.
@justtryme90
Please upvote and pour in your comments at https://steemit.com/sleep/@digitaldollar/is-it-sleep-paralysis-or-demon-attack
rs and upvote for you....
Thank you!
u r welcome
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
Babies come from when a mommy and daddy get in a cup and kiss. Noted.
Now this is the real take away message. :)
Lol
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
@justtryme90
I want to sincerely thank you for your generosity! You're a person of your word! You're awesome!!
It is I who am thankful to have people who are interested in the things that I post. It may not always seem like it, but I do not take any of it for granted.
I feel the same way....I really do!
wow~~
very interesting !!!
Thanks for reading and commenting.
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
thanks
You're welcome.
incredibly informative, thanks @justtryme90. stem cells are making waves in the medical world with more to come!
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
Thank you for reading and for your reply :)
Very awesome. I am so amazed at what we are beginning to be capable of with stem cells. Thank you for this post. :)
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
It's been a long time coming. This isn't even an application of any of the controversial stem cells (embryonic) but rather an "adult" stem cell variety.
This was really well done. You have a talent for explaining things in a way that the average person will not only understand, but find interesting. Plus, the humour was a nice touch!
I'm sure that your longer pieces are also well done, but your first attempt at a brief report was most definitely a success. Keep them coming! 🙂
Thanks very much, I won't let you down. :)
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
Thank you!
You're welcome. Have a nice day/night.
great article......but I think we have too many Humans on earth...no more.
Thanks for your comment and for reading :D
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
Nice post and an important finding by the team of reseachers. However, as you know it will take still a long time to understand if it may applicable in human use. That is always a big hurdle for researchers, as I experienced myself as researcher in drug discovery.
Positive side: every step one comes closer to a new solution.
Yes indeed. Taking the research and converting it into a human treatment is exceedingly slow. That is likely still 10-20 years away.
As was promised in the text, anyone who commented in this post would receive an equal share of the SBD portion of this posts rewards (converted into steem power) there were 12 total comments so your Steem Power share was 7.23 SP. Thank you for engaging me in my posts.
Much appreciated. Keep going the nice work.
Of course!