How does the Pfizer COVID vaccine work?/¿Cómo funciona la vacuna de Pfizer contra el COVID?

in #science4 years ago


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As you all know, our body is equipped with a system capable of protecting us from the pathogens that invade us, the so-called Immune System, which is responsible for generating the appropriate antibodies to kill these invading pathogens.

Como todos sabéis, nuestro cuerpo está dotado de un sistema capaz de protegernos de los patógenos que nos invaden, el llamado Sistema inmune, que se encarga de generar los anticuerpos adecuados para matar a estos patógenos invasores.

In addition, this immune system has a built-in memory system that allows it to remember these pathogens and kill them the next time they invade us, without giving them time to act and thus prevent them from infecting us and causing us harm.

Además este sistema inmune lleva incorporado un sistema de memoria que le permite recordar a estos patógenos y acabar con ellos la próxima vez que nos invadan, sin darles tiempo para que puedan actuar y así evitar que nos infecten y nos causen daño.

At the beginning of the 18th century, the British rural doctor Edward Jenner inoculated a child with smallpox pathogens obtained from the purulent wound of an infected with smallpox, the fact is that the boy survived and was immunized against smallpox.

A principios del siglo XVIII el médico rural británico Edward Jenner inocula a un niño agentes patógenos de viruela obtenidos de la herida purulenta de un infectado de viruela, con dos cojones, el caso es que el muchacho sobrevivió y quedó inmunizado contra la viruela.

After that episode, the entire population was vaccinated, after which they were kept in isolation for 40 days (quarantine) after which they were immunized for life against smallpox that we remember was a nightmare at that time.

Después de aquel episodio se empezó a vacunar a toda la población, tras lo cual se les mantenía aislados durante 40 días (cuarentena) pasados los cuales quedaban inmunizados de por vida contra la viruela que recordemos que era una pesadilla en aquella época.


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After this event and to this day, all vaccines work in the same way, inoculating a "stunned" version of the virus so that the patient's immune system is trained and can recognize it when the external virus, in good shape, attacks it again. and thus be able to finish him off.

Después de este evento y hasta nuestros días todas las vacunas funcionan de la misma manera, inoculando una versión "atontada" del virus para que el sistema inmune del paciente se entrene y pueda reconocerlo cuando el virus externo, en plena forma, lo vuelva a atacar y así poder acabar con él.

In the case of the Pfitzer vaccine, the methodology has completely changed and, to understand it, we have to know a little about how viruses work. All viruses, including COVID, are made up of a piece of RNA wrapped in a layer of fat and with spicules that they use as keys to enter the host cell.

En el caso de la vacuna de Pfitzer la metodología ha cambiado por completo y, para entenderlo, tenemos que conocer un poco cómo funcionan los virus. Todos los virus, incluido el COVID, están formados por un pedazo de ARN envuelto en una capa de grasa y con unas espículas que utilizan como llaves para entrar en la célula huésped.

Once the virus has entered the cell, it somehow hijacks it and forces it to replicate the virus instead of making the cell's own components until it bursts and the viruses spread throughout the body.

Una vez que el virus a entrado en la célula de alguna manera la secuestra y la obliga a replicar al virus en lugar de fabricar los componentes propios de la célula hasta que esta revienta y los virus se esparcen por el organismo.


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In the case of the Pfizer vaccine, instead of training the body to fight the virus with stunned specimens, they have developed a method to train the immune system to recognize and eliminate only the spicules of the virus, which means that it cannot enter in healthy cells.

En el caso de la vacuna de Pfizer, en lugar de entrenar al organismo para combatir al virus con ejemplares atontados, han desarrollado un método para entrenar al sistema inmune para reconocer y eliminar tan solo a las espículas del virus con lo cual éste no podrá entrar en las células sanas.

In this way, it is not necessary to inoculate the virus that, even if it is stunned, there is a potential risk of infection, the artificially synthesized RNA molecule degrades very quickly, thus avoiding potential risks and the worst that can happen is that the vaccine does not work effect.

De este modo no es necesario inocular el virus que, aunque esté apijotado, existe riesgo potencial de infección, la molécula de ARN sintetizada artificialmente se degrada muy rápido con lo que evitamos riesgos potenciales y lo peor que nos puede pasar es que la vacuna no surta efecto.

More information/Más información

https://www.nature.com/articles/s41565-020-00820-0

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At the beginning of the 18th century, the British rural doctor Edward Jenner inoculated a child with smallpox pathogens obtained from the purulent wound of an infected with smallpox, the fact is that the boy survived and was immunized against smallpox.

Jenner actually inoculated James Phipps (the child) with fluid from a cowpox blister, not from a smallpox blister. Source for this claim.

After this event and to this day, all vaccines work in the same way, inoculating a "stunned" version of the virus so that the patient's immune system is trained and can recognize it

This is false. Some vaccines work by introducing attenuated viral particles into the system of an individual, but not all vaccines function this way. Some vaccines use an inactivated pathogen, these so called vaccines are called inactivated vaccine. In this case the virus isn't stunned but the mechanisms for transmission and virality are destroyed (such as the destruction of the genetic material). Another type of vaccine is a sub-unit or recombinant vaccine which includes the pfizer vaccine. Recombinant vaccines work by taking a piece of the virus (either genetic material, capsid, certain spike proteins, etc) and using those pieces to trigger the immune response. The pfizer vaccine uses the RNA sequence for the spike protein which your cellular machinery will construct and then build an immune response against.Source 1 for this claim. Source 2 for this claim.

All viruses, including COVID, are made up of a piece of RNA wrapped in a layer of fat and with spicules that they use as keys to enter the host cell.

I mean this is incorrect as there are viruses that use DNA such as adenoviruses, herpesviruses, and poxviruses. Source for this claim.

edit: Further none of your images have their usage rights listed on the page you posted them from meaning that you very well could be committing copyright infringement and nobody would be able to double check.


Thanks for your comments, I am not an expert on the subject and it is always helpful if someone with more knowledge corrects me.
Regarding the last paragraph, do you mean that, in addition to including the link in "Source", I must name the web page of the photo explicitly?.Hi @myconerd: