I wonder how it would look if you tried it agaisnt a black background.....like colored chalk on a blackboard khan academy type look. I think it would help certain colors particularly yellow and overall be a bit easier on the eyes. Yellow is a pretty annoying color to use on a white background - https://www.sitepoint.com/10-troublesome-colors-to-avoid-in-your-advertising/ Then again it does say colors are hard to read agaisnt black background, so I'm not sure maybe that is a bad suggestion.
You should also talk with an animator at some point when you decide to try videos, I think that would work quite well.