The acceleration, as I understand it. But really, we needed to learn certain lessons about multimodule spacecraft first before attempting such a thing, and do it close enough to Earth that we could evacuate astronauts in a hurry if necessary.
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I guess the Russians are planning to detach some of the newer modules when the ISS is decommissioned and build a new space station out of them. So the entire thing won't be thrown away which is good. I guess over the lifespan of the space stations (Mir and ISS) eventually maintenance becomes such a significant fraction of the astronauts time that they can't do much research anymore.