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Santiago<--lat. Sant Iaco(bus)

Yes.

Santiago, (also San Tiago, Santyago, Sant-Yago, San Thiago) is a Spanish name that derives from the Hebrew name Jacob (Ya'akov) via "Sant Iago", first used to denote Saint James the Great, the brother of John the Apostle.

That is another example of the importance of transliterating names correctly, otherwise you end up with a completely different sounding name from the original.