It's known that in Adsense you have to use layouts and sizes that promote viewability of the ads, so they can be clicked, as it is a CPC system.
You have to be careful though because too many clicks (high ctrs) may be detected as invalid activity, and your account could be disabled (this decision might be for life).
If you want to make a huge income from Adsense, you need high CPCs. You need to bring tier 1 traffic to your site: this is from usa, canada, australia,....and also, if you are really looking to make a difference, your niche should be one of the profitable ones.