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RE: PNAs: An amazing molecular tool that can be converted into an effective antibiotic

It has not been found in nature and no known organisms can digest or transport it.

Yet!

I often worry there's nothing microbes can't do with a little bit of mutation!

But what you're describing sounds like a quite valuable addition to our arsenal against drug-resistant bacteria. Is it possible we've finally found the way to stop them? Very interesting.

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You're definitely right that bacteria can evolve to do almost anything so PNA degradation/interaction isn't out of the question once we start using PNAs to kill them.