Yeah, I guess researchers don't know exactly why this all is, they just found the connections between the miRs and tau.
Yep, lots of interesting findings, but not a clear picture of how it all pieces together. For that, we will need... more data.
Well, there have been clear established links to, for example, dairy and red meat consumption and AD, and those things are also linked to inflammation and poor circulatory health, and about a quarter of AD is vascular and AD itself is contemplated by some to be an inflammation-related disease so...
Yes and? Correlation is not causation. I just don't believe the data yet. I need more information and stronger relationships! I find a lot of things interesting, I just don't ascribe to any of it being the answer. If that makes any sense...
Yeah, more data is always nice. I do think the next few decades will be interesting as we've already seen increased incidents in countries that previously didn't have many, and more countries seem to be adopting a western lifestyle.
I don't think any single factor will ever be discovered to be the cause, I just think that a slew of factors increase the chance the brain reaches the tipping point where things start to go wonky and the brain is creating more tangles, failing to successfully create new neurons, and isn't properly flushing out the tangles during sleep.
Like, for example, statins, they say they aren't sure if they help or not, but on the one hand you have people who are perhaps suffering more from the vascular aspects and it might help them a bit more than others, but on the other hand it might make things worse for some if there is some interaction where it's interfering with myelin health.
Well that's sort of the deal with medicine, everything has a trade off. Incorporate drugs to modify aspects of your bodies function when the net effect will extend your life. Their ain't no such thing as a free lunch. I take hypertension medication, knowing full well that it's damaging my circulation. I must work to mitigate that damage, but irregardless, I would die much sooner from my blood pressure damaging my arteries and organs the opposite way, then I will from the BP meds.
Same goes for everything, statins are no excepton. They don't come with out a cost, but for some, that cost is less then not using.
I wish people thought more about what medications are, and didn't just think they were cost free.