Nice post, thanks for the info. One thing I have pondered for over a year (and I work with a lot of Alzheimer's and Dementia sufferers) is that this is the typical pit of 'correlation vs. causation'. A while back they identified the plaques and tangles and put their fingers firmly on Tau & beta-Amyloids as a source for treatment... however just because they are there, they are not necessarily the cause.
I skimmed though the comments and saw inflammation mentioned, and this is a very important issue. In the last 10 years neuroinflammation and exaggerated/chronic immune responses are surfacing as strong factors in neurodevelopmental disorders.
Add to that the recent discovery of a lymphatic vessel network within the brain that is capable of overcoming the blood-brain barrier, that can allow large proteins in the form of pathogens, allergens and other irritants in the brain and you have a cocktail for a whole new set of discoveries. I am really encouraged by the fact neuroimmunology and the relationship between brain and bowel is starting to be made as well. I think we are facing a layer cake and we have only tucked into the icing on top... It will be many decades before we can say we have really cracked neuropathology.
Upvoted for sure.
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Thanks for the v insightful comment!
I agree that we are very much at the beginning - and I think that applies to biotech in general. I really do believe that the next 20 years will be a golden era and in 2030 or so we will look back in amazement at how little we know right now
Cheers