One of the major problem faced in subunit vaccines is inability to form a store of long term memory B cells. I was just wondering a few days back that why not just screen for antibodies in-vitro and the CRISPR the B cells derived from pateints with the potent VDJ recombined gene. Then reinject them. Even better if you can differentiate them into memory subtype. This is a very cool paper. Thanks for sharing.
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