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Thank you :D
I showed here a bit of Aseprite: https://steemit.com/pixelart/@kristyglas/animated-potions-pixelart-weekly
And some older posts:
https://steemit.com/art/@kristyglas/lovecraftian-cthulhu
https://steemit.com/art/@kristyglas/pixel-art-weekly-contest-entry-magical-forest

Same process any program: I just use a pencil, not a brush and draw, usually on more layers. Once I'm done I sometimes adjust brightness and color. Also don't be afraid to change the canvas size even after you started. It's hard to guess perfect size from the first try. :)

most excellent, thank you! I have a few projects in which I'd like to do this kind of style but didn't really know where to start. Will read through your links for sure!

Sweet! Looking forward to it :D