I like what Ari Paul said about permissioned blockchains last year:
Yes - I think that banking, medical, and supply chain industries will be "transformed" by permissioned blockchains, but not because permissioned blockchains are new or interesting.
Rather - these industries simply never implemented other types of permissioned distributed ledgers that have been around for 50+ years. So now all of the focus on blockchain is pressuring them to finally upgrade their databases that are comically obsolete.
When you look at markets and supply chains, some are obviously better organized than others. When blockchain proposals are popular, that suggests a market failure - which could be solved by a centralized solution if there's an organization trusted by all participants.