I used to reply to each and every comment on my posts. As I learned that many of the comments were not genuine, I stopped and only responded to comments from people that seemed like they read my post. I used to upvote every comment on my posts too, but after learning that (for example) they left the same compliment on 27 other posts in the last few minutes, I started only upvoting the genuine comments.
I appreciate you taking the time to read my post and leaving a Genuine Comment!