I've definitely had a moment or two like that. Unfortunately the one I can remember caused a lot of hurt for another person, but I know it was necessary and the best move at the time. My friend had one professionally a while ago when he realized he didn't need to keep doing the grind like he thought and he was finally able to open his own business full time. He is so much happier now.
It opens new opportunities and allows us to move forward in one way or another and that's often personally rewarding.