I've gotta agree with the whole Boozer thing, but I honestly loved the reveal that Sarah was still alive.
Materials are plentiful and I would have liked more a system where you had to manage your inventory more. I think the story (at least up until the second halve) is top notched. I loved how the story tried to do something different, and the complexity that is Deacon St. John. In all honesty, I'd love a DLC where it explores his and Boozer's back story.
A concept for a second game was dismissed. Who knows they might come up with a new one though.