And I ask, what is the big deal if someone feels alienated?
Right, it's no big deal. Something every single human being encounters ever so often in life.
It's only a drama if you make one out of it. Those who feel alienated have the task of eliminating/working through the feeling of alienation themselves. It is not the responsibility of others to create a sense of familiarity in the self.
If I go to Japan and I don't speak the language, I don't expect all Japanese people to speak German. I de-alienate myself by learning to speak their language. If I don't like Japanese, well, there are plenty of other people I can learn to like.
That this person needs to be made to feel normal and healthy
by others, yeah, is bollocks in bags. It means I give up any remaining autonomy and self-reliance. I expect to be carried, comforted, understood by everyone like a baby and to have all my needs met pronto.
requires life long and drastic medicalization
That's the strange thing. It can be a lifelong dependency on pharmaceuticals. Who would voluntarily do that to themselves. If they do, then the need is really, really dire. And would reveal this whole sorry affair as a genuinely rare exception, which in reality it is. No norm. But ab-normality (which is just an ordinary term serving in contrast).