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Thome's career flourished in Philadelphia, where he achieved his highest home run total and further established himself in the annals of the game. His talents sparked a fourth-place MVP finish in 2003, and he celebrated his milestone 400th career home run shortly thereafter.
However, injuries began to take a toll in the mid-2000s, prompting a trade to the Chicago White Sox. Displaying resilience, he earned the Comeback Player of the Year award and hit his career-defining 500th home run in 2007.