"The cat is out of the bag" as they say, and no one can stop permissionless/open cryptocurrencies at this point.
But I think some people are going to have to learn the hard way, before they learn that self-custody is the way.
For some people it's a QuadrigaCX or an FTX, and for others maybe it'll be a Bitcoin/Ethereum ETF.
MicroStrategy will probably be the next big lesson, unfortunately.