Despite his initial happiness, Nostradamus's life took a devastating turn in 1534 when he lost his first wife and children, presumably to the plague while he was away on a medical mission. The shock of their demise profoundly affected him, resulting in a sense of disconnection from his community and a reevaluation of his life’s path. Eventually, after his second marriage to Anne, he sought to build a new life for his family as well as garner support for his intellectual pursuits, fostering an environment conducive to raising his children amidst the tumultuous backdrop of 16th-century France.
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