Opioids are indeed a problem and a big challenge in medicine research! I had neuropathic pain in my leg, before it was probably one of the worst pains since it doesn't matter if you stretch it, change position, etc. It is a pain caused by a damaged neuron, so it will be there until it is somehow healed. I remember that even opioids didn't help me much, they gave me tramadol. The only thing that helped me was some anti-depressants.
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