Lots to worry about.
But there is some hope from unintended consequences. Case in point: TOR was developed by the U.S. Navy. Now, it's used for anonymizing - and not just for sick stuff. Political dissidents have used TOR.
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I know... but these guys are talking about some bizzare stuff with a gleam in their eyes! Mixing the genomes of different species until we all (every species that is) has the same DNA- that way parts will be interchangeable. Now add nanotech into the mix. Human beings don't need to be "improved." We do not need to be immortal, except in an intellectual sense... Plato once wrote that if someone thinks enough of your ideas to quote you, you've achieved immortality. That's good enough for me (although I haven't come up with any ideas worth quoting yet).
One of these maniacs says "we have shaped the world's societies- now we can reshape ourselves." I hope we do a better job that we did with societies (but I don't see it happening). I don't know what your view of the Bible is but here's my take. From an historical standpoint- God created everything and put us in charge... we made it all the way to page 3 before we started fucking it up... Brave New World?... No thanks!!!