Grow apart or grow together.
It is often and unfortunately usually this way.
The struggles and experiences shared by you and your wife may not have always been pleasant, but they most probably brought you closer together. You walk a path hand in hand.
When it comes to family and friends, most cannot really even imagine the path you walk and therefore will grow apart. It may be that many still care for you and wish you well but feel they just have no connection. The divergence from their own path is too great. It can also be that jealousy plays a role for some or you have failed to meet the selfish expectations they have imagined for you. There are many reasons of course.
I have experienced similar since my move to Finland. I also experienced it here when I started my own company. Some that should be likely candidates to wish for my best have been the most judgemental and distancing. My approach is to wish them well and continue my path. Maybe we will cross paths again someday.
When it comes to being outspoken, we live in a world where many want to live in a fantasy. They worry about appearances and expectations. They avoid discomfort and remove anyone that questions their mental safety. Speaking out against what they feel is secure creates a risk for them so rather than investigating to understand more, they move away from or attack the challenger. People want to believe in their security, not discover it never existed. Again, if people want to sleep, let them sleep, wish them well and continue further down your path. Maybe when they finally awake, the way is a little easier for them to follow if they so choose.