The "tragedy of life" cannot possibly be encapsulated within just a line or two. It cannot be limited to death of something within us, and death itself be disclaimed as a tragedy. No. Tragedies lie more intricate and fragile and complex than that.
Each tragedy is different - of a different subjective magnitude to the one living it. Each has a different impact on all the souls it touches and tarnishes. Each tragedy acts off its own accord to carry on the tragic "dying of the inside"
But you cannot just evade tragedies by "following your heart" or "taking the high road." Although these cliches may sound nice and concrete, life is anything but. If you refuse to appreciate the greys, mold and evolve according to them, those areas of smoke where nothing can be anticipated, that's when the tragedies affect most, for the lack of diversity in your expectation and acceptance.
But if taking in account each and every possible impact and outcome of every situation and how you act in it - sometimes by killing your own id and ego, and perhaps letting the ones you love smile and unravel, that would hardly count as a tragedy, even if it were to kill you from inside.