Doesn't matter. If only blocks are distributed then it's really ineffective to grab such data as "who follows user x". Knowing who can give you block ranges is irrelevant info.
Reindexing whole blockchain with tags plugin turned on will get that information for fast access at the run time.
It's in network best interest to have seeders, not leechers.
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True. A more clever breakup may be by transaction type.
Ultimately it would even make sense to store monetary transactions in the main chain, text data in one side chain and big data (such as videos) in another.
(I lack culture on this, this is pure speculation)
Having smaller dataset may help having specialized seeders, meaning more seeders. Think of a seeder/cache node specialized in content written in one language.