RE: DRUG CONCEPTS, OPTOGENETICS AND WIRELESS STIMULATION OF BRAIN AND BODY IMPLANTS: a modern technology and approach to drug administration and treatment of diseases

[herbayomi]

This is an in-depth article!
I have got a question though, permit me if it does not sound biochemical/pharmaceutical enough.
What if the active component of the drug couldn't find a specific receptor on time or couldn't find it at all. What happens then?
I guess the molecules will leave circulation and be excreted as waste with urine. If I am right, is there a time frame for any drug's molecular components to remain in circulation?
If no, then what happens to them?

Comments

[cyprianj]

What if the active component of the drug couldn't find a specific receptor on time or couldn't find it at all. What happens then?

You rightly answered this.

To answer this

is there a time frame for any drug's molecular components to remain in circulation?

All drugs have half life and duration in which they are active. Some can even last for more than a day before excreted. Some even undergo enetero circulation in the body I. E they are reabsorbed in the large intestine and passes through the body system again still active e.g oral contraceptives.

Some can also last for just 30minutes or even lesser after which they are converted to water soluble and easily excretable xenobiotics through biotransformation in the liver.

In a nutshell, there is no specific general time frame for all drugs, they all have individuals duration at which they can stay in the body. Once they get to the liver, they are biotransformed by Cytochrome P450 enzyme and excreted either through urine or faeces.

Drugs will most likely accumulate in the body if the liver is not functional or maybe when the enzyme that is meant to catabolize the drug has been inhibited competitively by another drug.

pls Don't try this anywhere

Taking mebendazole aka actifed with alcohol is like getting closer to hell. It produces a disulfiram like effect. An unpleasant reaction that will make a chronic alcohol consumer to desist.

Likewise taking paracetamol with alcohol. Let me stop here before this turns into another post.

Thanks for this beautiful question

[herbayomi]

Wow! I asked for a little, I got a big fill!

All drugs have half life and duration in which they are active. Some can even last for more than a day before excreted. Some even undergo enetero circulation in the body I. E they are reabsorbed in the large intestine and passes through the body system again still active e.g oral contraceptives.

Re-absorption into entero circulation...got it!

In a nutshell, there is no specific general time frame for all drugs, they all have individuals duration at which they can stay in the body. Once they get to the liver, they are biotransformed by Cytochrome P450 enzyme and excreted either through urine or faeces. Drugs will most likely accumulate in the body if the liver is not functional or maybe when the enzyme that is meant to catabolize the drug has been inhibited competitively by another drug.

Understood! our Liver is one essential organ we shouldn't joke with.

Taking mebendazole aka actifed with alcohol is like getting closer to hell. It produces a disulfiram like effect. An unpleasant reaction that will make a chronic alcohol consumer to desist. Likewise taking paracetamol with alcohol.

Thanks for this waning. I would never try it.

This is a complete answer to my question... I had a good time here.
Thanks brother @cyprianj

[cyprianj]

This is the importance of interacting with post. The noble gentle bot just favoured you bro.
Congratulations

[herbayomi]

Haha... Really???

Thanks @gentlebot Hmm, you are right @cyprianj thanks for getting my attention. You started it, your article was superb and educative.

[cyprianj]

💖🙏