I have no doubt that AMLO will fight with the establishment in Mexico, but more important than if he does or not, is how he does it.
Look at the case of Venezuela, the establishment that governed from 1958-1999 was corrupt, kleptocratic and also leftist.
Chávez was anti-establishment, promised to put an end to corruption and criminality, he did not even say that he was a socialist, although as with AMLO, it could already be seen. Venezuela ended much worse than it started, and the failed establishment that was before Chávez has now gained prestige and national and international recognition as "democratic", or "free", and a lot of things that are far from reality.
I'm not saying that this is going to happen in Mexico, because they are two quite different countries, but I think there is a high probability that AMLO is not really a good option.
Venezuela was destroyed by the U.S. because Chavez was taking it off the petrodollar and repatriated his country's gold reserves. Today Trump is trying to maintain the empire through 'energy dominance' and Venezuela is being destroyed so that we can install a puppet to steal its reserves.
Obrador can and should work with Trump to expose the Clinton/Bush family connections to the Zetas and the other Cartels. Let's start with marijuana because the momentum is there. But, I think Trump's attacks on human trafficking and opioids are a smoke screen for going after the CIA drug trade which runs right through the heart of the US ruling families.
Mexico is a feudal society that is in need of overthrowing its oligarchy. Obrador's election is the hopeful beginning of that.
The crisis that Venezuela is experiencing today is a direct consequence of the measures that the government has taken. Venezuela is a country dependent on oil, and when the price of oil falls, the whole economy collapses, the modern crisis has had several precedents, at the beginning of the 60s, and also between the end of the 70s and the beginning of the 90s. The Venezuelan government had this knowledge and did not make any changes, its restrictions on the market, its attacks against private property, and the climate of institutional insecurity have diminished the entire capacity to foster an economy away from oil.
The United States has participated in several interventions around Latin America and the Middle East, I don't doubt it, but in the specific case of Venezuela it is not, the governments of Chávez and Maduro have failed on their own.
I also have no doubt that both American and Mexican politicians are favoring the drug trade, otherwise it would not take so much power, but leftist politicians in Latin America have a long tradition of contacts with drug traffickers, since they have always seen in the trade of drugs a stable financing method throughout the region. The contacts and relationships that AMLO has, in addition to its ideology, suggest that he is not the exception. Behind him is Slim and Soros.
Everyone agrees that Mexico needs a change in its political, social and economic structure, but not any change is good.
Not to mention Obama telling the DEA to stand down in relation to Hezbollah smuggling cocaine into the US